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糖基修飾的核苷酸

描述：糖基修飾的核苷

更新時間：2017-12-29
訪問次數：2787
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詳情介紹

糖基修飾的核苷酸（糖基修飾 DNA/RNA）

 核苷類藥物由于具有良好的抗病毒和抗腫瘤作用而在臨床上被廣泛應用,近年來隨著合成方法和藥學研究手段的進步,大量新型核苷化合物被制備并用于抗病毒和抗腫瘤的研究,如替比夫定（bivudine,L-dt）在2006年被FDA批準用于乙型肝炎的治療。但對一些致病率高的病毒感染如乙型肝炎,和惡性腫瘤現有藥物尚不能*解決問題,而且臨床治療中耐藥性問題日益突出,嚴重地阻礙了此類藥物的發展。因此尋找高效低毒的抗病毒和抗腫瘤核苷藥物一直是人們研究的熱點。 核苷類化合物的抗病毒和抗腫瘤作用機制大都是由于具有與天然核苷類似的結構,摻入病毒或腫瘤細胞的DNA鏈中,干擾其DNA和蛋白質的生物合成而起到抗病毒和抗腫瘤作用的。 核苷類化合物的修飾改造部位包括糖基和堿基部分,其中大部分為糖基修飾改造的產物。糖基改造修飾的類型包括無環核苷,脫氧核苷,雜原子引入,構型變化,糖環大小的變化等。

TriLink公司的糖基修飾的核苷列表：

N-1015-1

2'-O-Methyladenosine-5'-TP

1umole

467.5

N-1015-10

2'-O-Methyladenosine-5'-TP

10umoles

3485

N-1015-5

2'-O-Methyladenosine-5'-TP

5umoles

1955

N-1016-1

2'-O-Methylcytidine-5'-TP

1umole

467.5

N-1016-10

2'-O-Methylcytidine-5'-TP

10umoles

3485

N-1016-5

2'-O-Methylcytidine-5'-TP

5umoles

1955

N-1017-1

2'-O-Methylguanosine-5'-TP

1umole

467.5

N-1017-10

2'-O-Methylguanosine-5'-TP

10umoles

3485

N-1017-5

2'-O-Methylguanosine-5'-TP

5umoles

1955

N-1018-1

2'-O-Methyluridine-5'-TP

1umole

467.5

N-1018-10

2'-O-Methyluridine-5'-TP

10umoles

3485

N-1018-5

2'-O-Methyluridine-5'-TP

5umoles

1955

N-1021-1

2'-O-Methylinosine-5'-Triphosphate

1umole

1317.5

N-1021-10

2'-O-Methylinosine-5'-Triphosphate

10umoles

10625

N-1021-5

2'-O-Methylinosine-5'-Triphosphate

5umoles

6205

N-1026-1        

2'-Amino-2'-deoxycytidine-5'-TP

1umole

1317.5

N-1026-10

2'-Amino-2'-deoxycytidine-5'-TP

10umoles

10625

N-1026-5

2'-Amino-2'-deoxycytidine-5'-TP

5umoles

6205

N-1027-1        

2'-Amino-2'-deoxyuridine-5'-TP

1umole

1317.5

N-1027-10

2'-Amino-2'-deoxyuridine-5'-TP

10umoles

10625

N-1027-5

2'-Amino-2'-deoxyuridine-5'-TP

5umoles

6205

N-1028-1  

2'-Azido-2'-deoxycytidine-5'-TP

1umole

1317.5

N-1028-10

2'-Azido-2'-deoxycytidine-5'-TP

10umoles

10625

N-1028-5

2'-Azido-2'-deoxycytidine-5'-TP

5umoles

6205

N-1029-1        

2'-Azido-2'-deoxyuridine-5'-TP

1umole

1317.5

N-1029-10

2'-Azido-2'-deoxyuridine-5'-TP

10umoles

10625

N-1029-5

2'-Azido-2'-deoxyuridine-5'-TP

5umoles

6205

N-1033-1

Aracytidine-5'-Triphosphate

1umole

892.5

N-1033-10

Aracytidine-5'-Triphosphate

10umoles

7055

N-1033-5

Aracytidine-5'-Triphosphate

5umoles

4335

N-1034-1

Arauridine-5'-Triphosphate

1umole

1657.5

N-1034-10

Arauridine-5'-Triphosphate

10umoles

14450

N-1034-5

Arauridine-5'-Triphosphate

5umoles

7905

N-1040-1

2'-O-Methyl-2-aminoadenosine-5'-TP

1umole

1317.5

N-1040-10

2'-O-Methyl-2-aminoadenosine-5'-TP

10umoles

10625

N-1040-5

2'-O-Methyl-2-aminoadenosine-5'-TP

5umoles

6205

N-1041-1

2'-O-Methylpseudouridine-5'-TP

1umole

892.5

N-1041-10

2'-O-Methylpseudouridine-5'-TP

10umoles

7055

N-1041-5

2'-O-Methylpseudouridine-5'-TP

5umoles

4335

N-1043-1        

2'-O-Methyl-5-methyluridine-5'-TP

1umole

892.5

N-1043-10

2'-O-Methyl-5-methyluridine-5'-TP

10umoles

7055

N-1043-5

2'-O-Methyl-5-methyluridine-5'-TP

5umoles

4335

N-1045-1

2'-Azido-2'-deoxyadenosine-5'-TP

1umole

1317.5

N-1045-10

2'-Azido-2'-deoxyadenosine-5'-TP

10umoles

10625

N-1045-5

2'-Azido-2'-deoxyadenosine-5'-TP

5umoles

6205

N-1046-1      

2'-Amino-2'-deoxyadenosine-5'-TP

1umole

892.5

N-1046-10

2'-Amino-2'-deoxyadenosine-5'-TP

10umoles

7055

N-1046-5

2'-Amino-2'-deoxyadenosine-5'-TP

5umoles

4335

N-1048-1    

Araadenosine-5'-TP

1umole

1317.5

N-1048-10

Araadenosine-5'-TP

10umoles

10625

N-1048-5

Araadenosine-5'-TP

5umoles

6205

N-1056-1      

3'-O-Methyladenosine-5'-TP

1umole

1317.5

N-1056-10

3'-O-Methyladenosine-5'-TP

10umoles

10625

N-1056-5

3'-O-Methyladenosine-5'-TP

5umoles

6205

N-1057-1

3'-O-Methylcytidine-5'-TP

1umole

1317.5

N-1057-10

3'-O-Methylcytidine-5'-TP

10umoles

10625

N-1057-5

3'-O-Methylcytidine-5'-TP

5umoles

6205

N-1058-1        

3'-O-Methylguanosine-5'-TP

1umole

1317.5

N-1058-10

3'-O-Methylguanosine-5'-TP

10umoles

10625

N-1058-5

3'-O-Methylguanosine-5'-TP

5umoles

6205

N-1059-1 

3'-O-Methyluridine-5'-TP

1umole

1317.5

N-1059-10

3'-O-Methyluridine-5'-TP

10umoles

10625

N-1059-5

3'-O-Methyluridine-5'-TP

5umoles

6205

N-1063-1

2'-Azido-2'-deoxyguanosine-5'-TP

1umole

1317.5

N-1063-10

2'-Azido-2'-deoxyguanosine-5'-TP

10umoles

10625

N-1063-5

2'-Azido-2'-deoxyguanosine-5'-TP

5umoles

6205

N-2053-1

2'-Deoxy-L-adenosine-5'-TP

1umoles

　

N-2053-10

2'-Deoxy-L-adenosine-5'-TP

10umoles

14450

N-2053-5

2'-Deoxy-L-adenosine-5'-TP

5umoles

7905

N-2054-1

2'-Deoxy-L-cytidine-5'-TP

1umole

1657.5

N-2054-10

2'-Deoxy-L-cytidine-5'-TP

10umoles

14450

N-2054-5

2'-Deoxy-L-cytidine-5'-TP

5umoles

7905

N-2055-1

2'-Deoxy-L-guanosine-5'-TP

1umole

2975

N-2055-10

2'-Deoxy-L-guanosine-5'-TP

10umoles

24650

N-2055-5

2'-Deoxy-L-guanosine-5'-TP

5umoles

13175

N-2056-1

2'-Deoxy-L-thymidine-5'-TP

1umole

1657.5

N-2056-10

2'-Deoxy-L-thymidine-5'-TP

10umoles

14450

N-2056-5

2'-Deoxy-L-thymidine-5'-TP

5umoles

7905

N-3001-1

3'-Deoxyadenosine-5'-Triphosphate

1umole

1317.5

N-3001-10

3'-Deoxyadenosine-5'-Triphosphate

10umoles

10625

N-3001-5

3'-Deoxyadenosine-5'-Triphosphate

5umoles

6205

N-3002-1

3'-Deoxyguanosine-5'-Triphosphate

1umole

1317.5

N-3002-10

3'-Deoxyguanosine-5'-Triphosphate

10umoles

10625

N-3002-5

3'-Deoxyguanosine-5'-Triphosphate

5umoles

6205

N-3003-1

3'-Deoxycytidine-5'-Triphosphate

1umole

1317.5

N-3003-10

3'-Deoxycytidine-5'-Triphosphate

10umoles

10625

N-3003-5

3'-Deoxycytidine-5'-Triphosphate

5umoles

6205

N-3004-1

3'-Deoxy-5-Methyluridine-5'-TP

1umole

1317.5

N-3004-10

3'-Deoxy-5-Methyluridine-5'-TP

10umoles

10625

N-3004-5

3'-Deoxy-5-Methyluridine-5'-TP

5umoles

6205

N-3005-1

3'-Deoxyuridine-5'-Triphosphate

1umole

1317.5

N-3005-10

3'-Deoxyuridine-5'-Triphosphate

10umoles

10625

N-3005-5

3'-Deoxyuridine-5'-Triphosphate

5umoles

6205

N-4001-1

2',3'-Dideoxyadenosine-5'-TP

1umole

467.5

N-4001-10

2',3'-Dideoxyadenosine-5'-TP

10umoles

3485

N-4001-5

2',3'-Dideoxyadenosine-5'-TP

5umoles

1955

N-4002-1

2',3'-Dideoxyguanosine-5'-TP

1umole

467.5

N-4002-10

2',3'-Dideoxyguanosine-5'-TP

10umoles

3485

N-4002-5

2',3'-Dideoxyguanosine-5'-TP

5umoles

1955

N-4003-1

2',3'-Dideoxyuridine-5'-Triphosphate

1umole

467.5

N-4003-10

2',3'-Dideoxyuridine-5'-Triphosphate

10umoles

3485

N-4003-5

2',3'-Dideoxyuridine-5'-Triphosphate

5umoles

1955

N-4004-1   

2',3'-Dideoxythymidine-5'-Triphosphate

1umole

467.5

N-4004-10

2',3'-Dideoxythymidine-5'-Triphosphate

10umoles

3485

N-4004-5

2',3'-Dideoxythymidine-5'-Triphosphate

5umoles

1955

N-4005-1

2',3'-Dideoxycytidine-5'-Triphosphate

1umole

467.5

N-4005-10

2',3'-Dideoxycytidine-5'-Triphosphate

10umoles

3485

N-4005-5

2',3'-Dideoxycytidine-5'-Triphosphate

5umoles

1955

N-4007-1

3'-Azido-2',3'-dideoxyadenosine-5'-TP

1umole

1657.5

N-4007-10

3'-Azido-2',3'-dideoxyadenosine-5'-TP

10umoles

14450

N-4007-5

3'-Azido-2',3'-dideoxyadenosine-5'-TP

5umoles

7905

N-4008-1

3'-Azido-2',3'-dideoxyguanosine-5'-TP

1umole

1657.5

N-4008-10

3'-Azido-2',3'-dideoxyguanosine-5'-TP

10umoles

14450

N-4008-5

3'-Azido-2',3'-dideoxyguanosine-5'-TP

5umoles

7905

N-4009-1

3'-Azido-2',3'-dideoxythymidine-5'-TP

1umole

1657.5

N-4009-10

3'-Azido-2',3'-dideoxythymidine-5'-TP

10umoles

14450

N-4009-5

3'-Azido-2',3'-dideoxythymidine-5'-TP

5umoles

7905

N-4010-1

3'-Amino-2',3'-dideoxyadenosine-5'-TP

1umole

2975

N-4010-10

3'-Amino-2',3'-dideoxyadenosine-5'-TP

10umoles

24650

N-4010-5

3'-Amino-2',3'-dideoxyadenosine-5'-TP

5umoles

13175

N-4011-1

3'-Amino-2',3'-dideoxycytidine-5'-TP

1umole

2975

N-4011-10

3'-Amino-2',3'-dideoxycytidine-5'-TP

10umoles

24650

N-4011-5

3'-Amino-2',3'-dideoxycytidine-5'-TP

5umoles

13175

N-4012-1

3'-Amino-2',3'-dideoxyguanosine-5'-TP

1umole

2975

N-4012-10

3'-Amino-2',3'-dideoxyguanosine-5'-TP

10umoles

24650

N-4012-5

3'-Amino-2',3'-dideoxyguanosine-5'-TP

5umoles

13175

N-4013-1

3'-Amino-2',3'-dideoxythymidine-5'-TP

1umole

1657.5

N-4013-10

3'-Amino-2',3'-dideoxythymidine-5'-TP

10umoles

14450

N-4013-5

3'-Amino-2',3'-dideoxythymidine-5'-TP

5umoles

7905

N-4014-1

3'-Azido-2',3'-dideoxycytidine-5'-TP

1umole

1657.5

N-4014-10

3'-Azido-2',3'-dideoxycytidine-5'-TP

10umoles

14450

N-4014-5

3'-Azido-2',3'-dideoxycytidine-5'-TP

5umoles

7905

N-4015-1

3'-Azido-2',3'-dideoxyuridine-5'-TP

1umole

1657.5

N-4015-10

3'-Azido-2',3'-dideoxyuridine-5'-TP

10umoles

14450

N-4015-5

3'-Azido-2',3'-dideoxyuridine-5'-TP

5umoles

7905

N-4016-1       

5-Bromo-2',3'-dideoxyuridine-5'-TP

1umole

1657.5

N-4016-10

5-Bromo-2',3'-dideoxyuridine-5'-TP

10umoles

14450

N-4016-5

5-Bromo-2',3'-dideoxyuridine-5'-TP

5umoles

7905

N-4017-10

2',3'-Dideoxyinosine-5'-TP

10umoles

20995

N-4017-5

2',3'-Dideoxyinosine-5'-TP

5umoles

11815

N-9001-1

Ganciclovir-5'-Triphosphate

1umole

1317.5

N-9001-10

Ganciclovir-5'-Triphosphate

10umoles

10625

 

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